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Compass Publishing brings Jules Verne's early science fiction underwater epic to its line of Compass Classic Readers. English language learners of all ages will enjoy developing their vocabulary and reading fluency as they read about a sea expedition that leads to the enigmatic captain Nemo and his amazing submarine, the Nautilus. Students and teachers alike will be amazed by this science fiction landmark of men who are witness to awesome demonstrations of undersea majesty and technological power.

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• Sales Rank: #3978065 in Books
• Published on: 2009-03-01
• Binding: Perfect Paperback
• 76 pages

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[D877.Ebook] Free PDF Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications, by Malcolm Rowland, Thomas N. Tozer PharmD PhD

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Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.

• Sales Rank: #357622 in Books
• Brand: Brand: Lippincott Williams Wilkins
• Published on: 2010-01-28
• Original language: English
• Number of items: 1
• Dimensions: 9.90" h x 1.50" w x 7.20" l, 3.85 pounds
• Binding: Hardcover
• 864 pages

Features

• Used Book in Good Condition

Review
-- "This textbook covers a tremendous range of topics important in pharmacokinetics and pharmacodynamics. No other textbook does this as effectively as the Rowland and Tozer text." -- "I believe this book is the best written text for bridging the gap between basic PK and clinical PK."

Most helpful customer reviews

30 of 30 people found the following review helpful.
Great book, the gold standard intro
By model man
This book is a very finely crafted comprehensive introduction to pharmacokinetics, with enough pharmacodynamics to give one context. If you are new to PK/PD and need to understand and work with the subject matter this is an EXCELLENT starting point and a fine reference. The prose is clear, the organization thoughtful, and the figures and diagrams are masterful - best in class. The authors are both renowned academics with extensive industrial experience. That background shines through in the thoughtful way that topics are motivated and explained. I found the questions useful and thought-provoking. Isn't it the case that the more iron one pumps in the gym, the stronger one is on the playing field?
One thing that I would add to this book (and most other PK books I've seen) would be a comprehensive listing of the different math models (one or two compartment, IV, or zero or first order input, etc), highlighting different uses (closed form solutions are easiest to use for parameter estimations, ODE formulations for repeat dosing, etc.) and their different parameterizations. This book contains some of this information (e.g. Table 19-1), but an appendix with this info would be useful. An additional improvement with great teaching utility might be an elementary modeling/estimation program for MS-Excel.
For those needing an overview of PK (e.g. a pharma executive responsible for a development program) without a lot of the details necessary for practitioners, a less-comprehensive book that is also very good is Peter Welling's "Pharmacokinetics". Gabriellson's and Weiner's book "PK and PD Data Analysis" has a more spotty overview of the basic subject matter, but does have descriptions of many techniques not found elsewhere. The latter book is "WinNonLin-centric" (WinNonLin is a program written by one of the authors) which may be what is wanted.
My favorite intro book and basic referencer for PK is definitely Rowland and Tozer. Bravo!

2 of 2 people found the following review helpful.
Best reference on PK
By Tyler Barbour
This excellent book (1980 edition) was my introduction to this topic. I have it in my bookshelf and I keep referring back to it. Without planning it, I've become the resident PK expert in my department thanks to this reference! Thank you Drs. Rowland and Tozer.

3 of 4 people found the following review helpful.
The Bible of Pharmcokinetics
By Richard Wolf Wong
"Clinical Pharmacokinetics: Concepts and Applications" (or better known as Rowland and Tozer) is a book filled with deep concepts and good explanations. It is the Bible of Pharmacokinetics. If there is a PK concept you want to look up, this book will be the first place you look for it. Before giving the review, let me introduce my background. I have a formal education in physical chemistry and analytical chemistry and am currently working in the field of pharma. I have currently read through half of this book. Although I have not completely finishing the book, I believe there is enough information to share.

The previous PK book I read was Concepts In Clinical Pharmacokinetics by Joseph T. Dipiro and it is a shorter and simpler book than Rowland and Tozer. While "Concepts In Clinical Pharmacokinetics" was a delight to read, it is on the simpler side and a lot of concepts are left unexplained. When I was reading it, there were often moment of "How did he get from this to that?" or "Where this comes from?", and I had to stop reading and tried to derive the equations. In contrast, Rowland and Tozer explain the principles of PK in great details and often from multiple angles, so that the readers can fully appreciate how the concepts are linked together, how PK theories apply and how PK impacts pharmacology research and the drug discovery. The exercises are challenging, but not impossible. Well, a few of them are nearly impossible, but most of them can be worked out (even for someone of my background).

I would love to give it a 4.5 stars, but that is not an option. I do see there are a few shortcomings in this book. Although it is very detailed, it can be too detailed for beginners, except for students who has more time. It is best to start off with a short and easy to read introductory book. Yes, Rowland and Tozer have explained many concepts in multiple ways and this is generally good, except when you are busy. Sometime, I just feel like: I get your point already. The Final and the real criticism is that the book can be a bit dry. Unlike "Concepts In Clinical Pharmacokinetics", this is not a book to be breezed through.

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• Sales Rank: #4449624 in Books
• Published on: 2009-09-01
• Original language: English
• Number of items: 1
• Dimensions: 9.49" h x .83" w x 6.54" l,
• Binding: Paperback
• 561 pages

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0 of 0 people found the following review helpful.
Three Stars
By Amazon Customer
Received book in good condition. Hurray!

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• Sales Rank: #952763 in Books
• Published on: 2006-07-21
• Original language: English
• Number of items: 1
• Dimensions: 9.50" h x 1.40" w x 6.50" l, 2.71 pounds
• Binding: Hardcover
• 792 pages

About the Author
Averill Law is President of Averill M. Law & Associates, Inc. (Tucson, AZ), a company specializing in simulation training, consulting, and software. He was previously Professor of Decision Sciences at the University of Arizona and Associate Professor of Industrial Engineering at the University of Wisconsin-Madison. He has a Ph.D. and an M.S. in industrial engineering and operations research from the University of California at Berkeley, an M.A. in mathematics from California State University at Long Beach, and a B.S. in mathematics from Pennsylvania State University. Dr. Law has been a simulation consultant to organizations such as Accenture, ARCO, Boeing, Booz Allen & Hamilton, Defense Modeling and Simulation Office, Hewlett-Packard, Kaiser Aluminum, Kimberly-Clark, M&M/Mars, Navy Modeling and Simulation Office, SAIC, Sandia National Labs, Swedish Defence Material Adminstration, and Xerox. He has presented more than 400 simulation short courses in 17 countries, including in-house seminars for ALCOA, AT&T, Boeing, Caterpillar, Coca-Cola, CSX, GE, GM, IBM, Intel, Lockheed Martin, Los Alamos National Lab, Missile Defense Agency, Motorola, NASA, National Security Agency, Nortel, Northrop Grumman, 3M, Time Warner, UPS, US Air Force, US Army, US Navy, Whirlpool, and Xerox. He is the developer of the ExpertFit distribution-fitting software, which automates the selection of simulation input probability distributions. ExpertFit is used by more than 2000 organizations worldwide. He also developed the videotapes Simulation of Manufacturing Systems and How to Conduct a Successful Simulation Study. Dr. Law is the author (or coauthor) of three books and numerous papers on simulation, operations research, statistics, manufacturing, and communcations networks. His article "Statistical Analysis of Simulation Output Data" was the first invited feature paper on simulation to appear in a major research journal. His series of papers on the simulation of manufacturing systems won the 1988 Institute of Industrial Engineers' best publication award. During his academic career, the Office of Naval Research supported his simulation research for 8 consecutive years. He was President of the INFORMS College on Simulation. He wrote a regular column on simulation for Industrial Engineering during 1990 and 1991. He has been the keynote speaker at simulation conferences worldwide.

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4 of 4 people found the following review helpful.
Bible for Operations Research / Statistical Analysis
By bigmomma
Law is about as authoritative as you can get for M&S / Operations Research and systems analysis (ORSA). If you are building a library or need a comprehensive reference for advanced studies or your analytic work, it is probably no surprise that this book would be highly recommended. Not necessarily for the lay person, you need some fundamental skills in mathematics, statistics, probability etc. to really leverage the information in this book. I used a previous version in graduate school 20 years ago and HAD to add this to my work reference library.

3 of 4 people found the following review helpful.
5-stars; like a good prostate exam
By randomdude1978
This was a tough one to rate... Amazon has a qualitative equivalent for each star rating level; 1-star is "I hate it", 2-stars is "I don't like it", 3-stars is "It's okay", 4-stars is "I like it", and 5-stars is "I love it". This qualitative equivalent sometimes puts me at odds on how I want to rate something. I'll try to give an example of something that is more common to people than a sim book. I'm a guy and I'm at the age where I'm *supposed* to go in for a yearly check-up. As part of this yearly check-up the doctor sticks his finger in your rectum to help determine if you have prostate problems. Now let's say I have word renowned doctor that is an expert in determining prostate problems and he performs this activity, and let's say he does a 5-star job. Do I now have to say that I loved this procedure? So most of you can now see the conundrum here. To say I loved this book would be like saying I love having someone stick their finger in my rectum to inspect my prostate. On the other hand, this is a great analogy to me for reading mathematically intensive books. They were necessary for my education and the knowledge I obtained from them continues to be necessary for my career. So when I give this book a 5-star review, it is not because I love this book, it is because this book does a good job at setting out to convey knowledge about simulation modeling and analysis concepts.

Btw, this book is very mathematically intensive (for me anyway); especially in terms of statistical analysis. In my career I work around a lot of physics based simulations and "entity-level" simulations for defense related scenarios, so I had some misconceptions about the class that I used this book in. However, it was required for my Masters degree, so sometimes you have to just have to bend over and start reading.

4 of 5 people found the following review helpful.
Warning: Special Indian Edition
By Trevor
It is not stated in the description, but this book is the "Special Indian Edition" for sale in India, Pakistan, Nepal, Bangladesh, Sri Lanka and Bhutan only. The contents are in English, but I have no idea if the material is the same as the standard edition.

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• Sales Rank: #15295154 in Books
• Published on: 2008-02-29
• Original language: English
• Number of items: 1
• Dimensions: 8.50" h x .73" w x 5.51" l, .91 pounds
• Binding: Paperback
• 324 pages

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• Number of items: 1
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• Published on: 1987
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